Urinary markers for bladder cancer

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Urinary markers for bladder cancer

Bladder cancer has the fifth highest incidence of all malignancies in the United States, with a propensity to recur, requiring lifelong surveillance after diagnosis. Urinary markers of disease have been of extreme interest in this field in an effort to simplify surveillance schedules and improve early detection of tumors. Many markers have been described, but most remain investigational. Howeve...

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Urinary markers in bladder cancer.

OBJECTIVES Many markers for the detection of bladder cancers have been tested. Almost all urinary markers reported are better than cytology with regard to sensitivity, but they score lower in specificity. The purpose of this review is to highlight the most important urinary biomarkers studied and reported recently. METHODS Literature on bladder cancer markers has been reviewed regularly in th...

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Urinary Tumor Markers for Bladder Cancer

Description of Procedure or Service Populations Interventions Comparators Outcomes Individuals:  With signs and symptoms of bladder cancer or a history of bladder cancer Interventions of interest are:  Urinary tumor marker tests Comparators of interest are:  Cytology  Cystoscopy  Biopsy Relevant outcomes include:  Overall survival  Disease-specific survival  Test accuracy  Test validit...

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Cytology and Urinary Markers for the Diagnosis of Bladder Cancer

Primary detection and follow-up of patients with non–muscle-invasive (NMI) bladder cancer (BC) is done by urethro-cystoscopy (UCS) and, in most cases, cytology. Many urine-based tests have been developed, and in general, these tests have a higher sensitivity than cytology but a lower specificity. In this review, we assessed the value of urine tests for screening, primary detection, and surveill...

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Germline prognostic markers for urinary bladder cancer: obstacles and opportunities.

Urinary bladder cancer is a heterogeneous disease with diverse genetic and environmental risk factors that can influence disease risk or clinical course for recurrence, progression, and survival. Therefore, identification of these factors is paramount for disease prevention and optimal clinical management of bladder cancer patients. Of particular interest is the need to identify molecular bioma...

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ژورنال

عنوان ژورنال: F1000Prime Reports

سال: 2013

ISSN: 2051-7599

DOI: 10.12703/p5-21